Platelet-Derived Growth Factor Receptor β But Not α Mediates Cardiac Fibrosis In Vitro and In Vivo
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چکیده
منابع مشابه
Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.
OBJECTIVE Knockout studies have demonstrated crucial roles for the platelet-derived growth factor-B and its cognate receptor, platelet-derived growth factor receptor-beta (PDGFR-beta), in blood vessel maturation, that is, the coverage of newly formed vessels with mural cells/pericytes. This study describes the consequences of a constitutively activating mutation of the PDGFR-beta (Pdgfrb(D849V)...
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ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2017
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2017.06.225